Tony Breu
Hospitalist, VA Boston. Assistant Professor, @harvardmed and @HMSbioethics. Co-host, @CuriousClinPod. Usually at #AMreport. Views are my own.
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1/15 Why is torsemide my preferred loop diuretic when treating heart failure? As a follow-up to a recent tweetorial on furosemide and gut edema, let me offer a 3-part ode to torse...
1/17 [Why] is furosemide susceptible to malabsorption from "gut edema"? When a patient with heart failure is hospitalized with congestion I often hear "let's use IV furosemide; t...
1/13 Why does adrenal insufficiency (particularly adrenal crisis) lead to hypotension? I don't think of glucocorticoids as "pressors" and yet when they're lacking patients are at...
1/15 Why are statins administered at night? In this tweetorial I'll discuss the mechanistic and historical reasons for the frequently used QHS dosing schedule. And why it's often...
1/16 Why do we use a vaccine (BCG) to treat an unrelated malignancy (bladder cancer)? Can infections really prevent/treat cancer? Let's find out.
1/15 Why does clostridium difficile infection (CDI) cause marked leukocytosis? Many of you have likely seen a new WBC >20k and wondered "could this patient have CDI?" Are you rig...
1/11 Why is alkaline phosphatase elevated in biliary obstruction? This question was debated for decades. The current explanation is NOT what I had expected. Will you be surprised...
1/12 Why do we use ACE inhibitors in scleroderma renal crisis? I learned this early in training but never understood why these drugs were so game-changing. Let's have a look. ht...
1/14 How does fever help us fight infections? For millennia, fever has been recognized as a beneficial response to invading pathogens. If this is so, why don't we have a resting...
1/14 Why is cerebrospinal fluid (CSF) glucose low in bacterial meningitis? Before we review potential mechanisms, I'm interested in the explanation you've heard/used. What do you...
1/16 Why do B12 and folate deficiencies lead to HUGE red blood cells? And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected...
1/17 How does calcium "stabilize the cardiac membrane" in hyperkalemia? I learned early in my intern year to use calcium in the setting of severe hyperkalemia. I never really lea...