Relationship between SARS-CoV-2 viral dynamics during acute infection & development of #LongCOVID:
A NEW study finds that the longer the time from peak viral load to viral RNA clearance during acute COVID-19, the higher risk of developing #LongCOVID. 1/
A NEW study finds that the longer the time from peak viral load to viral RNA clearance during acute COVID-19, the higher risk of developing #LongCOVID. 1/
Researchers analysed 7361 asymptomatic people between Oct’ 2021 and Feb’ 2022 who collected swabs for SARS-CoV-2 RT-PCR every 24-48 hours for 10-14 days, regardless of symptom or infection status. 2/
Participants who had no history of COVID-19 at enrollment and who were subsequently found to have at least 1 positive SARS-CoV-2 RT-PCR test during the parent study were recontacted in August 2023 and asked whether they had experienced long COVID. 3/
Participant's cycle threshold (Ct) values were converted into viral loads, and slopes of viral clearance were modeled using post-nadir viral loads. 4/
Researchers calculated the relative risk of subsequently developing long COVID with 1-2 symptoms, 3-4 symptoms, or 5+ symptoms, adjusting for age, number of symptoms, and SARS-CoV-2 variant. 5/
Results:
1-172 participants were eligible for analyses, and 34.3% reported experiencing longCOVID.
2-The risk of #longCOVID with 3-4 symptoms and 5+ symptoms increased by 2.44 times & 4.97 times per viral load slope-unit increase, respectively. 6/
1-172 participants were eligible for analyses, and 34.3% reported experiencing longCOVID.
2-The risk of #longCOVID with 3-4 symptoms and 5+ symptoms increased by 2.44 times & 4.97 times per viral load slope-unit increase, respectively. 6/
3-Participants who developed #longCOVID had significantly longer times from peak viral load to viral clearance during acute disease than those who never developed longCOVID (8.65 vs. 10.0) 7/
4-The slope of viral clearance was significantly positively associated with longCOVID symptoms of fatigue (aRR: 2.86), brain fog (aRR: 4.94), shortness of breath (aRR: 5.05), and gastrointestinal symptoms (aRR: 5.46). 8/
Conclusions:
1- The researchers observed that longer time from peak viral load to viral RNA clearance during acute COVID-19 was associated with an increased risk of developing long COVID. 9/
1- The researchers observed that longer time from peak viral load to viral RNA clearance during acute COVID-19 was associated with an increased risk of developing long COVID. 9/
2-Slower clearance rates were associated with greater number of symptoms of longCOVID.
3-These findings suggest that early viral-host dynamics are mechanistically important in the subsequent development of longCOVID. 10/10
medrxiv.org.
3-These findings suggest that early viral-host dynamics are mechanistically important in the subsequent development of longCOVID. 10/10
medrxiv.org.
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