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أهلا وسهلا فيكم أصدقاءنا الأعزاء 🌿
نكمل معكم سلسلة مواضيعنا عن
💊Antifungal medications💊
🌟 اليوم مع دواء مهم جدا في هذي المجموعة ألا وهو...
✳️Micafungin✳️
#SCPreparation
نكمل معكم سلسلة مواضيعنا عن
💊Antifungal medications💊
🌟 اليوم مع دواء مهم جدا في هذي المجموعة ألا وهو...
✳️Micafungin✳️
#SCPreparation
💊Micafungin💊
⏩ is a semisynthetic lipopeptide antifungal agent, inhibits the synthesis of 1,3 beta-D-glucan, a fundamental constituent of fungal cell walls.
⏩ is a semisynthetic lipopeptide antifungal agent, inhibits the synthesis of 1,3 beta-D-glucan, a fundamental constituent of fungal cell walls.
💠Indications:
⏩Candidemia
⏩Candidiasis of the esophagus
⏩Invasive candidiasis, Hematopoietic Stem Cell Transplantation; Prophylaxis
⏩Invasive candidiasis, Peritonitis or abscess
⏩Aspergillosis
⏩Candidemia
⏩Candidiasis of the esophagus
⏩Invasive candidiasis, Hematopoietic Stem Cell Transplantation; Prophylaxis
⏩Invasive candidiasis, Peritonitis or abscess
⏩Aspergillosis
💠Doses:
👨 Adult:
✳️Candidemia
⏩100 mg once daily as IV infusion over 1 hour; mean duration of therapy in clinical studies was 15 days.
👨 Adult:
✳️Candidemia
⏩100 mg once daily as IV infusion over 1 hour; mean duration of therapy in clinical studies was 15 days.
✳️Candidiasis of the esophagus:
⏩150 mg/day IV infusion over 1 hour; mean duration of therapy 15 days (range 10 to 30 days; FDA dosage)
150 mg/day IV for 14 to 21 days (guideline dosage)
⏩150 mg/day IV infusion over 1 hour; mean duration of therapy 15 days (range 10 to 30 days; FDA dosage)
150 mg/day IV for 14 to 21 days (guideline dosage)
✳️Aspergillosis, Invasive
⏩100 to 150 mg IV once daily for at least 6 to 12 weeks (guideline dosage)
⏩100 to 150 mg IV once daily for at least 6 to 12 weeks (guideline dosage)
👶 Pediatrics:
✳️Candidemia:
⏩(Younger than 4 months, without meningoencephalitis and/or ocular dissemination) 4 mg/kg once daily as IV infusion over 1 hour
(4 months or older) 2 mg/kg once daily as IV infusion over 1 hour; MAX 100 mg/day
✳️Candidemia:
⏩(Younger than 4 months, without meningoencephalitis and/or ocular dissemination) 4 mg/kg once daily as IV infusion over 1 hour
(4 months or older) 2 mg/kg once daily as IV infusion over 1 hour; MAX 100 mg/day
✳️Candidiasis of the esophagus:
⏩(30 kg or less) 3 mg/kg IV infusion over 1 hour once daily
(greater than 30 kg) 2.5 mg/kg IV infusion over 1 hour once daily; MAX 150 mg/day
⏩(30 kg or less) 3 mg/kg IV infusion over 1 hour once daily
(greater than 30 kg) 2.5 mg/kg IV infusion over 1 hour once daily; MAX 150 mg/day
✳️Aspergillosis, Invasive
⏩(4 months or older, 40 kg or less) 2 to 3 mg/kg IV once daily for at least 6 to 12 weeks (guideline dosage)
(4 months or older, more than 40 kg) 100 to 150 mg IV once daily for at least 6 to 12 weeks (guideline dosage)
⏩(4 months or older, 40 kg or less) 2 to 3 mg/kg IV once daily for at least 6 to 12 weeks (guideline dosage)
(4 months or older, more than 40 kg) 100 to 150 mg IV once daily for at least 6 to 12 weeks (guideline dosage)
✨نتجه الان للجزء العملي…
✨Patient Osama 48 years old, his weight 90 kg, the serum Creatinine for the patient
0.75mg/dl the patient admitted to ICU, suspected to have Candidemia…
0.75mg/dl the patient admitted to ICU, suspected to have Candidemia…
✨The Physician ordered for the patient Micafungin 100mg IV once daily over 1 hour for at least 10 days ..
Standard Concentration =
0.5mg/ml
Maximum Concentration =
1.5mg/ml
Standard Concentration =
0.5mg/ml
Maximum Concentration =
1.5mg/ml
✨we will use the standard concentration because the serum creatinine for the patient normal…
✨The total volume =
Dose/Concentration
The total volume =
100mg/0.5mg/ml =200ml
✨The Diluent = 0.9% Normal Saline
✨The total volume =
Dose/Concentration
The total volume =
100mg/0.5mg/ml =200ml
✨The Diluent = 0.9% Normal Saline
✨The Diluent Volume =
We will reconstitution the 100mg by 5 ml 0.9% Normal saline slowly to minimize foaming, gentle swirl to dissolve ; do not shake …
The Diluent Volume =
200ml - 5 ml = 195ml
We will reconstitution the 100mg by 5 ml 0.9% Normal saline slowly to minimize foaming, gentle swirl to dissolve ; do not shake …
The Diluent Volume =
200ml - 5 ml = 195ml
✨Infusion Time = 60 min
✨Infusion Rate =
🛑Infusion Rate should be ml/hr or ml/min🛑
✨Infusion Rate =
3.3ml/min
✨Stability =
24 hrs in Room temperature
✨BUD = 25/6/2021 8:20 PM🕣
🛑Protect from the light🛑
✨Infusion Rate =
🛑Infusion Rate should be ml/hr or ml/min🛑
✨Infusion Rate =
3.3ml/min
✨Stability =
24 hrs in Room temperature
✨BUD = 25/6/2021 8:20 PM🕣
🛑Protect from the light🛑
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