اهـلا وسهـلا فيكم صيادلتنا الأعزاء ،
نكمل معاكم سلسلة تغريداتنا عن Antibiotics
اليوم معانا
💊Colistimethate Sodium 💊
#SCPreparation
نكمل معاكم سلسلة تغريداتنا عن Antibiotics
اليوم معانا
💊Colistimethate Sodium 💊
#SCPreparation
💉💉Colistin 💉💉
Colistin, also known as polymyxin E, is an antibiotic for multidrug-resistant Gram negative infections.
Colistin, also known as polymyxin E, is an antibiotic for multidrug-resistant Gram negative infections.
🚫Black Box Warnings🚫
🔴Colistin should be reserved for use in situations when alternative treatments are not suitable.
🔴Colistin should be reserved for use in situations when alternative treatments are not suitable.
💊Doses for adult 💊
The dose is expressed in international units (IU) of colistimethate sodium (CBA).
The dose is expressed in international units (IU) of colistimethate sodium (CBA).
💊Loading adult dose: 9 million units =(300mg) and it can reach up to 12 million units in patient with good renal function.
💊maintenance dose: 9MIU/day in 2-3 divided doses
=(2.5-5mg/kg divided)
💊maintenance dose: 9MIU/day in 2-3 divided doses
=(2.5-5mg/kg divided)
👦🏼Pediatric dose:75,000-150,000 IU/kg/day divided into 3 doses.
=(2.5-5 mg/kg/day) in divided doses.
=(2.5-5 mg/kg/day) in divided doses.
🧠Colistin also Can be given as intraventicular and intrathecal (Colistin should be preservatives free to given by these routes)
The daily recommended dose for intraventecular dose is 125000Units/day
The daily recommended dose for intraventecular dose is 125000Units/day
🚨The intrathecal dose should not exceed the intraventricular dose.
🚨Colistin need dose adjustment
🚨Colistin need dose adjustment
قبل مانروح للجزء العملي 🌝 عندنا نقطه مهمه مثل مالاحظتم في الجدول عندنا ثلاثه وحدات مهمه ..
مثل ماتلاحظون في الجدول..
Colistin9000000unit
CMS=720mg
CBA=300mg
في التحضير نعتمد فقط على ال
9000000IUorCMS=720mg
ونعتمد على CBA في حساب الجرعه فقط..
الان نروح للجانب العلمي والاهم😉
مثل ماتلاحظون في الجدول..
Colistin9000000unit
CMS=720mg
CBA=300mg
في التحضير نعتمد فقط على ال
9000000IUorCMS=720mg
ونعتمد على CBA في حساب الجرعه فقط..
الان نروح للجانب العلمي والاهم😉
✨Patient Ahmed 75 years old, his wight 95kg the Serum Creatinine 0.65mg/dl admitted in the ICU has multi-drug resistant bacteria Acinetobacter baumannii, carbapenemase-producing E.coli and Klebsiella and his obtained culture resistance to all antibiotics except Colistin.
⬇️
⬇️
✨The physician ordered Colistin 9000000 IU=300mg as initial dose then 4500000 IU=150mg Every 12 hours as maintenance dose...
The Standard Concentration =
20000 IU/ml
The Maximum Concentration =
40000 IU/ml
The Standard Concentration =
20000 IU/ml
The Maximum Concentration =
40000 IU/ml
✨We will start with the initial dose...
We will use the standard concentration because the serum creatinine for the patient normal...
The Total Volume =
Dose/Concentration
The Total Volume =
9000000IU/20000IU/ml
The Total Volume =
450ml
The Diluent = 0.9% N/S
We will use the standard concentration because the serum creatinine for the patient normal...
The Total Volume =
Dose/Concentration
The Total Volume =
9000000IU/20000IU/ml
The Total Volume =
450ml
The Diluent = 0.9% N/S
The Diluent Volume=
We will Reconstitution the 1000000IU by 4.9ml SWFI
It’s mean the 9000000 IU will be in 45ml
The Diluent Volume =450ml-45ml=405ml
Stability = 24 hr in Refrigerator
BUD =29/11/2020 8:00 PM 🕗
We will Reconstitution the 1000000IU by 4.9ml SWFI
It’s mean the 9000000 IU will be in 45ml
The Diluent Volume =450ml-45ml=405ml
Stability = 24 hr in Refrigerator
BUD =29/11/2020 8:00 PM 🕗
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