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Acute Kidney Injury (AKI):
Thread on guide to Diagnosis and Management
Thread on guide to Diagnosis and Management
Throughout this thread we will review some developments about the Dx and Tx of AKI
Some contraversial points also will be discussed inshaallah 🤍🍃
Some contraversial points also will be discussed inshaallah 🤍🍃
Definition of AKI: is an abrupt loss of Kidney function +/- oliguria +/- anuria.
The resulting effect include:
👇🏻👇🏻👇🏻
Remember🔎: AKI is usually Reversible decline in the eGFR 🤲🏻
The resulting effect include:
👇🏻👇🏻👇🏻
Remember🔎: AKI is usually Reversible decline in the eGFR 🤲🏻
What is important to know that our precious organ (kidneys) received 25% of our cardiac output ♥️ and that our lovely filtring units (Nephrons) filters approximately 180L’s water 💦 daily without a stop 🛑 . Almost (125 mL / min ) of our plasma 🧪
📝Note:
The normal value for eGFR is influenced by many factors
1- age
2- muscle mass (body size)
3- gender (👨🏻, 👩🏻)
4- Race
📝Note:
The normal eGFR value varies between 👩🏻/👨🏻, for the previous reason related to muscle mass/body size
📝Note:
No EXACT eGFR can be calculated
The normal value for eGFR is influenced by many factors
1- age
2- muscle mass (body size)
3- gender (👨🏻, 👩🏻)
4- Race
📝Note:
The normal eGFR value varies between 👩🏻/👨🏻, for the previous reason related to muscle mass/body size
📝Note:
No EXACT eGFR can be calculated
What is important to know as a practitioner is wheathr the estimated Glomerular filtration Rate is Changing 😦 or stable 😃
Ext Point Is Very Important: 🚨
The difference between the following terminologies
👇🏻👇🏻👇🏻
Acute Kidney Disease /AKD
Acute Kidney Injury / AKI
Acute Renal Failure / ARF
Are they interchangable ?
Which one is the most accurate to use when you want to describe ur patient 🔎
The difference between the following terminologies
👇🏻👇🏻👇🏻
Acute Kidney Disease /AKD
Acute Kidney Injury / AKI
Acute Renal Failure / ARF
Are they interchangable ?
Which one is the most accurate to use when you want to describe ur patient 🔎
The term AKI ✅ (ACUTE KIDNEY INJURY) replaced the previously used ARF ( acute renal failure) ❌
Why?
Bcuz the smaller changes ↕️ in kidney function without evident FAILURE can result in 🛑 SIGNIFICANT Clinical Consequences ✋🏻 then ⬆️ mortality 💀⬆️morbidity
Why?
Bcuz the smaller changes ↕️ in kidney function without evident FAILURE can result in 🛑 SIGNIFICANT Clinical Consequences ✋🏻 then ⬆️ mortality 💀⬆️morbidity
REMEMBER 💡
AKI = ⏰⬆️7️⃣Days
⬇️3️⃣Months
The duration of injury is not included in the definition , but has been shown to be related to prognosis 🚦🥊🏆🎭
AKI = ⏰⬆️7️⃣Days
⬇️3️⃣Months
The duration of injury is not included in the definition , but has been shown to be related to prognosis 🚦🥊🏆🎭
AKI & CKD often form a continium of disease! they are not a separate conditions
Many disease midifiers & risk factors may represent a chance to mediate the poor outcomes that usually associated with AKI
Disease modifiers , Risk Factors , poor outcomes 👇🏻👇🏻👇🏻
Many disease midifiers & risk factors may represent a chance to mediate the poor outcomes that usually associated with AKI
Disease modifiers , Risk Factors , poor outcomes 👇🏻👇🏻👇🏻
Important TimeLine 😃 for days post any injury
Worth to remember 👩🏻🏫 👍🏻
⏰AKI= 48Hr —> ⬇️7️⃣days
⏰AKD=⬆️7️⃣days -> ⬇️3️⃣month
⏰CKD 💀 = ⬆️3️⃣month &continue
Worth to remember 👩🏻🏫 👍🏻
⏰AKI= 48Hr —> ⬇️7️⃣days
⏰AKD=⬆️7️⃣days -> ⬇️3️⃣month
⏰CKD 💀 = ⬆️3️⃣month &continue
Remember 💡
Recovery from AKI within 48Hrs of the initial injury represent
RAPID REVERSAL 💃🏻 💃🏻 🏆✋🏻
Recovery from AKI within 48Hrs of the initial injury represent
RAPID REVERSAL 💃🏻 💃🏻 🏆✋🏻
Patients who suffer AKD<< with preexisting 🥊 CKD 🥊 are at HIGH RISK of Kidney Disease PROGRESSION 💀
Disease Epidemiology
ATN accounts in ICU patients is caused by Sepsis in 35%-50% of cases
ATN = Acute Tubular Necrosis
ATN = Acute Tubular Necrosis
ICU = Higher Mortality usually ⌛️⏳
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